Based on the Pop Culture film, Mean Girls High School edition follows Cady Heron, a teenager homeschooled on the African savanna, who transitions to public high school in Chicago, Illinois. She navigates the cutthroat social dynmaics of high school, encountering the "Plastics", led by the ruthless Regina George. Cady's attempts to infiltrate the Plastics and become popular lead her to learn some valuable life lessons about self-acceptance, authenticity, and kindness.